关键词: 补肾中药;卵巢摘除;骨质疏松;骨密度;骨生物力学

    中图号:R339.38

    摘 要:目的 研究补肾中药佳蓉片(JRP)对模型小鼠骨质疏松的影响. 方法 雌性昆明小鼠60只随机分为6组，行去卵巢术或假手术.处理后分组为:去卵巢组(OVX)，假手术组(Sham)，去卵巢分为佳蓉片低剂量组(JRP-L，100mg·d-1 )，佳蓉片中剂量组(JRP-M，200mg·d

    -1 )，佳蓉片高剂量组(JRP-H，400mg·d-1 )和17β雌二醇组(E2，10μg·d-1 ).手术后灌胃上述药物28d，测定股骨密度、骨生物力学性能、血清碱性磷酸酶(ALP)、骨钙素(BGP). 结果 各中药组的股骨骨密度均高于去卵巢对照组(P<0.05)，与假手术组无差异;灌胃中药后骨结构力学参数显著性改善(P<0.05)，同时ALP，BGP显著性降低(P<0.05). 结论 补肾中药方剂可预防去卵巢引起的骨丢失，改善骨的生物力学性能.

    Kidney tonifying recipes prevents bone loss in ovariectomized mice

    YANG Hai-Yan，CHEN Ya-Qiong，HUANG Yan-Hong，XIN Xiao-Yan，WU Shu-uang

    Department of Gynaecology and Obstetrics，Xijing Hospital，Fourth Military Medical University，Xi'an710033，China，Institute of Materia Medica，First Military Medical University

    Keywords:kidney-tonifying recipes;osteoporosis;ovariec-tomized;bone mineral density;bone biomechan-ics

    Abstract:AIM To investigate the efficacy and mechanism of kidney tonifying recipes(JRP)in preventing osteoporosis.METHODS Seventy two-month-old Kunming female mice were divided into6groups(n=10).Ten mice were sham-op-erated(Sham)and treated by daily oral gavage with vehicle ......