关键词: 鼻咽癌;超微结构;形态;定量

    中图号:R760

    摘 要:目的 探讨鼻咽癌病理学发生发展进程中的形态学特点与规律. 方法 应用体视学技术，在超微结构水平，对人鼻咽部正常假复层纤毛柱状上皮、鼻咽癌旁异型增生/化生上皮和鼻咽癌3种上皮细胞核的形态改变进行了定量测试.用于定量分析的体视学参数包括Vvn，Svn，Nvn，Vve，vn，sn共6个参数. 结果 6个参数按正常鼻咽上皮→癌旁上皮→癌的顺序逐渐增大，且差异具有显著性. 结论 提示鼻咽癌病理发展存在一个由正常上皮→异型增生/化生→癌的逐步渐进的过程，异型增生/化生的上皮应作为癌前病变予以关注.

    Sterological quantitative study of ultrastructure on morphological development of nasopharyngeal car┐cinoma

    YANG Xing-Long，SHEN Hong，ZONG Yong-Sheng

    Department of Gastroenterology，Nanfang Hospi-tal，Department of Oncology，First Military Medi-cal University，Guangzhou510515，China，Department of Pathology，Sun Yat-Sen University of Medical Sciences

    Keywords:nasopharyngeal carcinoma;ultrastructure;mor-phology;quantiation

    Abstract:AIM To study the law of morphological changes during pathological development of nasopharyngeal carcino┐ma.METHODS Normal nasopharyngeal epithelia，para-cancerous nasopharyngeal carcinoma(NPC)epithelia and tis-sue of nasopharyngeal carcinoma cell's were taken as studying samples.The morphological changes of above three epithelial cell's nuclei were measured by means of stereological meth-ods at electronic microscopical levels.Vvn ......