关键词: 尾部悬吊大鼠;头高位;基底动脉;血管反应

    中图号:R852.22

    摘 要:目的 间断性人工重力被认为是对抗长期失重下心血管系统脱适应的最有效、合理措施之一.本实验拟探讨其对抗模拟失重下大鼠脑基底动脉血管反应性改变的影响. 方法 每日给予3wk尾部悬吊大鼠不同持续时间(2h或4h)的头高位倾斜(HUT)，测定大鼠离体基底动脉血管环对KCl的收缩反应性. 结果 悬吊组大鼠基底动脉血管环对KCl的最大反应(7.07±0.49)mN较对照组(4.83±0.36)mN显著升高(P<0.05);HUT组大鼠基底动脉血管环对KCl的最大反应[HUT4 :(4.78±0.51)mN;HUT2 :(5.56±0.28)mN]较悬吊组显著减弱(P<0.05)，与对照组无显著差异. 结论 采用头高位作为人工重力刺激可对抗模拟失重对大鼠脑动脉血管反应性的影响.

    Counteracting effects of intermittent head┐up tilt on changes in responsiveness of basilar arteries of tail┐suspended rats

    ZHANG Le-Ning，CAO Xin-Sheng，MA Jin，ZHANG Li-Fan，WU Xing-Yu，WU Yan-Hong

    Department of Aerospace Physiology，Department of Aerospace Biodynamic，Faculty of Aerospace Medicine，Fourth Military Medical University，Xi'an710033，China

    Keywords:tai-suspension rats;head-up tilt;basilar artery;vascular responsiveness

    Abstract:AIM Artificial gravity is considered one of the most effective and rational countermeasures to cardiovascular deconditioning after spaceflight.The purpose of this work is to investigate counteracting effects of intermittent artificial gravity on changes in responsiveness of basilar arteries of tail-suspended rats.METHODS Three-wk Tail-suspended rats were subjected to head-up tilt(HUT)of various dura-tion(2h or4h ......