关键词: 肝硬化;乙型肝炎;白细胞介素-6;白细胞介素-8;肿瘤坏死因子

    摘 要:目的 探讨血清IL-6，IL-8及TNF-α与肝硬化病情演化关系. 方法 用放射免疫分析法检测40例肝硬化患者血清中IL-6，IL-8，TNF-α含量. 结果 肝硬化合并腹水患者血清IL-6，IL-8及TNF-α水平分别为(0.35±0.15)μg·L-1 ，(0.36±0.08)μg·L-1 及(25±8)pmol·L-1 ，明显高于正常对照组(P<0.05).肝硬化合并腹水感染者血清中IL-6，IL-8及TNF-α分别为(0.51±0.19)μg·L-1 ，(0.64±0.12)μg·L-1 及(33±8)pmol·L-1 ，明显高于无腹水感染组(P<0.01).IL-6，IL-8及TNF-α含量随Child-Pugh分级的递增而增高. 结论 IL-6，IL-8及TNF-α在肝硬化病情进展中起着重要作用.提示利用IL-6，IL-8及TNF-α拮抗剂或其他方法阻断这一环节，对减缓肝硬化患者肝功能恶化有一定的临床意义.

    Significance of serum IL┐6，IL┐8，TNF┐αfrom pa┐tients with cirrhosis after hepatitis B

    ZHANG Jin-Zhang，HUANG Yu-Xin，WEN Qin-Sheng，ZHAO Bao-Min

    Department of Gastroenterology，Tangdu Hospital，Fourth Military Medical University，Xi'an710038，China

    Keywords:liver cirrhosis;hepatitis B;interleukin-6;inter-leukin-8;tumor necrosis factor-α

    Abstract:AIM To study the relationship between the serum IL-6，IL-8and TNF-αlevels and various Child classifi-cations in patients with liver cirrhosis.METHODS Serum IL-6，IL-8and TNF-αlevels were detected by radioim-munoassay method in40cases of liver cirrhosis.RESULTS Serum IL-6 ......