关键词: 骨折愈合;病理改变;血流量

    摘 要:目的 研究骨折愈合过程中病理改变与血流量变化规律，并探讨其间的关系. 方法 在兔左侧桡骨中段制作骨折动物模型，应用单光子放射计算机断层成像术(SPECT)测定骨折端不同时相点血流量变化，并取骨折端标本脱钙进行光镜和电镜观察. 结果 伤后24h内骨折端病理改变以组织坏死和炎症反应为主要变化，72h～3wk出现极为活跃的修复细胞增生，8wk基本达到骨性愈合.伤后8h骨折端血流量已出现升高，1wk时达到最高点，这种高血流状态一直持续到第3周，5wk时有所回降，至骨折后8wk恢复到正常水平. 结论 骨折端修复细胞活跃期与局部血流量增加的高峰期相吻合，增生活跃的修复细胞可能产生某种因子，该因子与局部血流量增加有关.

    Changes of pathology and blood flow at fracture sites in process of fracture healing

    CHU Tong-Wei，WANG Zheng-Guo，ZHU Pei-Fang ，WEN Jian-Liang，JIN Rong-Bing，ZHANG Bo

    1 Research Institute of Surgery，2 Department of Ra-diation，Third Military Medical University，Chongqing400042，China

    Keywords:fracture healing;pathological change;blood flow

    Abstract:AIM To study the changing pattern and relation between pathology and blood flow at fracture sites in the pro-cess of fracture healing.METHODS Animal fracture mod-els were made in the left radius of rabbits，then the blood flow at fracture site was measured by SPECT(single photon emission computerized tomography) ......