关键词: 康复;脑梗死;基因，Fos;热休克蛋白质类70

    摘 要:目的 研究康复训练对脑梗死大鼠大脑皮质Fos，Hsp70表达的影响. 方法 采用60只SD大鼠制作脑梗死模型;1d后随机分为康复组和制动组;康复组每天给予平衡、抓握、旋转、行走等训练，制动组置于网状笼内固定，各组在1，7，14，21和28d检测Fos，Hsp70蛋白表达. 结果 康复组和制动组大鼠大脑皮质出现Fos和Hsp70阳性反应神经元，康复组反应明显较制动组强，对侧较梗死侧多. 结论 康复训练可激活脑梗死大鼠大脑梗死灶周围和对侧相应皮质神经元功能，促进运动功能恢复.

    Effects of rehabilitation training on the expression of Fos and Hsp70in the cortex of cerebral infarcted rats

    LI Ling，YUAN Hua，MU Xiang，XU Li

    Department of Physiotherapy and Rehabilitation，Xijing Hospital，Fourth Military Medical Universi-ty，Xi'an710033，China

    Keywords:rehabilitation;cerebral infarction;genes，Fos;heat shock proteins70

    Abstract:AIM To study the effect of rehabilitation training on the expression of Fos and Hsp70in the cortex of cerebral infarcted rats.METHODS Sixty SD rats were given cere-bral infarction and divided into2groups at random1d later:rehabilitation group was given balancing，grasping，rotating and walking exercises everyday，while immobilization group was fixed in cages.Immunohistochemistry was used to intect the Fos and Hsp70expression1，7，14，21and28d after in-farction respectively.RESULTS Fos-like immune reaction and Hsp70active neurons appeared in cortex of both sides. ......