关键词: 5-羟色胺;神经系统;免疫细胞化学;大鼠

    中图号:R322.81

    摘 要:目的 观察大鼠神经系统内5-HT5A 受体亚型(5-HT5A R)的定位分布. 方法 5-HT5A R特异性抗体的免疫细胞化学染色技术. 结果 5-HT5A R阳性神经元主要分布于斜角带核、终纹床核、视上核、室旁核、下丘脑前区、下丘脑腹内侧核、下丘脑外侧区、弓状核、视交叉上核、乳头体上核、杏仁基外侧核、蓝斑、面神经核、舌下神经核、中缝隐核、中缝苍白核、孤束核以及三叉神经节和脊神经节. 结论 5-HT5A R阳性结构比较广泛地分布于大鼠神经系统，5-HT可能通过5-HT5A R实现对神经系统多种功能活动的调控.

    Localization of5┐HT5A receptor subtype in the rat nervous system

    WANG Ya-Yun，WU Sheng-Xi，LI Yun-Qing

    Department of Anatomy and K.K.Leung Brain Re-search Centre，Faculty of Preclinical Medicine，Fourth Military Medical University，Xi'an710033，China

    Keywords:5-HT;nervous system;immunocytochemistry;rat

    Abstract:AIM To observe the distribution of5-HT5A recep-tor subtype(5-HT5A R)in the rat nervous system.METHODS Immunocytochemical staining technique was ap-plied by using specific antibody against5-HT5A R.RESULTS 5-HT5A R immunoreactive neurons were observed in the horizontal nucleus diagonal band，bed nucleus of the stria ter-minalis，supraoptic nucleus，paraventricular nucleus，anteri-or hypothalamic area，ventromedial hypothalamic nucleus ......