Keywords:vitiligo;melanocytes

    autoantibodies CLC number:R758.41

    Abstract:AIM To probe into the clinical features and the cause of vitiligo.METHODS Clinical data of2008patients with vitiligo were reviewed;anti-pigment cell IgG antibodies in the sera of283patients with vitiligo was detected by ELISA;anti-pigment cell IgG antibodies and IgM antibodies in the sera of45patients with vitiligo were detected by Im-munohistological methods;cytotoxic experiment mediated by complement was studied with the sera of25patients with ac-tive vitiligo.RESULTS ①Of the total2008vitiligo pa-tients，the male-to-female ratio was1.06.The average age of the patients at visit was23.2years old.The average of the onset age was20years old.There were6patients who fell ill when they were born.Head and neck were the most involved locations.Unilateral type was of the most.82.2%patients were in advancing stage when they came to see the doctor.303patients(15.0%)were accompanied with other diseases.110(5.5%)of them were accompanied with halo nevi.156(7.8%)patients have family history.337(16.4%)patients confirmed provocated factors.②Of the sera of25patients with active vitiligo ......