关键词: 骨质疏松症;大鼠;骨密度;生物力学

    摘 要:目的 探讨雌激素减少对皮质骨骨密度及生物力学特性的影响. 方法 用雌性大鼠去势建立绝经后骨质疏松症动物模型，观察去势后6wk及12wk大鼠胫骨骨密度及股骨屈服点载荷、载荷/变形、最大应力以及弹性模量的变化. 结果 去势6wk骨密度与屈服点载荷、载荷/变形、最大应力以及弹性模量与对照组相比无显著差异(P>0.05)，而去势12wk组骨密度明显低于对照组(P<0.01)，而屈服点载荷、载荷/变形、最大应力以及弹性模量均低于对照组(P<0.05). 结论 骨密度和生物力学参数的测量对于骨质疏松症动物模型的建立及治疗骨质疏松症药物疗效的判断有重要的意义.

    Bone mineral density and biomechanical properties of the cortical bone in ovariectomized rats

    HAN Li-Hua，WANG Quan-Ping，LIU Jian，LI Xiao-Juan，HOU De-Men

    1 Institute of Orthopaedics of Chinese PLA，Xijing Hospital，Fourth Military Medical University，Xi'an710033，China，2 Department of Strength of Materials，School of Civil Engineering and Mechan-ics，Xi'an Jiaotong University，Xi'an710049，China

    Keywords:osteoporosis;rat;bone mineral density;biome-chanics

    Abstract:AIM To explore the effects of bone mineral den-sity and biomechanical properties of the cortical bone in o-variectomized(OVX)rats.METHODS An animal model of postmenopausal osteoporosis was established by ovariec-tomized rats and the change in tibia bone mineral density and femur yield point load ......