关键词 :膀胱肿瘤;受体，血小板源生长因子;新生血管化，病理性;免疫组织化学

    摘 要:目的 探讨血小板衍生生长因子受体(PDGFR)表达与膀胱移行上皮细胞癌发生、生物学行为及预后的关系. 方法 采用免疫组织化学技术——两步法检测68例膀胱移行细胞癌和10例正常膀胱组织PDGFR表达及膀胱癌组织中微血管密度(MVD). 结果 PDGFR阳性染色分布于癌细胞、间质、血管及炎症细胞的胞质及胞膜.膀胱癌组织PDGFR阳性率为83.8%，明显高于正常膀胱组织(30.0%，P<0.01)，膀胱癌组织中PDGFR阳性表达组的微血管密度(MVD)明显高于PDGFR阴性表达组(85±30vs36±15，P<0.01). 结论 PDGFR表达与正常膀胱组织生长有关，过度表达与癌的形成、血管的形成及炎症细胞功能相关，未发现PDGFR表达与肿瘤分期、分级及预后相关.

    Expression of platelet┐derived growth factor recep┐tor in human bladder carcinoma

    QIN Jun，CHEN Bao-Qi，LIU Dian-Cheng

    Department of Urology，Xijing Hospital，Fourth Military Medical University，Xi'an710033，China

    Keywords:bladder neoplasms;receptors，platelet-dervied growth factor;neovascularization，pathologic;im-munohistochemistry

    Abstract:AIM To study the relationship between expres-sion of platelet-derived growth factor receptor(PDGFR)and the genesis，biological behavior and prognosis of bladder transitional cell carcinoma.METHODS Expression of PDGFR and microvessel density(MVD)were investigated in68cases of transitional cell carcinoma in bladder and10cases of normal bladder tissues with immunohistochemical ......