(1 Department of Gastroenterology，2 Department of Medical Affairs，4 Department of Interventional Radiology，Tangdu Hospital，Fourth Military Medical University，Xi'an710038，China，3 Department of Immunology，Faculty of Preclinical Medicine，Fourth Military Medical University，Xi'an710033，China)

    Keywords:brain-gut peptide;electro-acupuncture;neuro se-cretory systems/immunology;immunoreactions CLC number:R246 Document code:A

    Abstract:AIM To investigate the role of brain-gut peptides in the electro-acupuncture regulated neuroendocrine-immune network as well as its mechanism.METHODS The rats were randomized into5groups，including the control，the Tsusanli，the immunosuppressive model，the non-acupoint group，and the Tsusanli+immunosuppressive groups.The Tsusanli group rats，fixed，were electro-acupunctured at Tsusanli(He-Sea Point，St36)on both sides continually for30min at any point between07:00and09:00for7d on a dai-ly basis.The location of the acupoints for EA:Tsusanli(He-Sea Point，St36)was identified at approximately5mm be-low the small end of the fibula on the outer lower side of knee joint hind limb of the rats and the non-acupoint was0.5cm beyond Tsusanli.Changes in substance P(SP)and vasoac-tive intestinal peptide(VIP)contents in the pituitary gland and peripheral blood were determined by radioimmunoassay.T-lymphocytic subgroups were assayed to reflect the cellular immunity.Erythrocytic immunity was assayed by red blood cell C3b receptor rosette(RBC-C3b RR)and red blood cell im-mune complexes rosette(RBC-ICR).RESULTS After EA ......