关键词: 脾虚;胃肠活动;缩胆囊素;生长抑素 中图号:R223.1 文献标识码:A

    摘 要:目的 探讨脾虚证时胃肠激素改变与胃肠运动异常之间的关系. 方法 采用放射免疫分析法测定实验性脾虚证大鼠不同造模时间(7d，14d)，胃窦、十二指肠、空肠、下丘脑及血浆中生长抑素(SS)、缩胆囊素(CCK)含量并与正常对照组和四君子汤预防组比较.通过体内埋藏电极和传感器记录胃、肠电—机械活动进行造模前后自身比较. 结果 脾虚早期(7d)，SS在下丘脑、血浆中含量升高，外周组织中含量下降(P<0.01).CCK在组织和血浆中含量均升高(P<0.01).胃电—机械活动节律、振幅均下降(P<0.01).肠机械活动节律、振幅均升高(P<0.01)，电慢波节律下降，振幅升高(P<0.01).脾虚晚期(14d)，SS在下丘脑、血浆中含量下降，外周组织中含量升高(P<0.01).CCK在下丘脑及胃窦组织中含量升高(P<0.01)，在血浆和肠道组织中含量下降(P<0.01).胃机械活动节律下降(P<0.01)，振幅改变不明显.电慢波节律、振幅均下降(P<0.01).肠电—机械活动节律、振幅均下降(P<0.01).经四君子汤预防性治疗的动物体内激素含量及胃、肠电—机械活动变化均无显著性意义. 结论 脾虚证时胃肠激素改变与胃肠运动异常之间存在内在联系，且随病程发展呈动态变化.四君子汤对此有纠正作用.

    Relationship between variation of gastrointestinal hormones and disorder of gastrointestinal motility in Pixu

    LIU Fang，REN Ping，LI Yue-Cai，HUANG Xi

    1 Department of Gerontology，2 Department of Tradi-tional Chinese Medicine，Xijing Hospital，Fourth Military Medical University，Xi'an710033，China

    Keywords:spleen deficiency;gastrointestinal motility;chole-cystokinin;somatostatin

    Abstract:AIM To explore the relationship between the variation of gastrointestinal hormones and the disorder of gastrointestinal motility in pixu.METHODS Pixu rat mod-els(n=60)were treated by reserpine for seven days and fourteen days respectively.The somatostatin(SS)and chole-cystokinin(CCK)levels in tissues and plasma of the rat mod-els was measured by RIA.The normal group and the group prevented and treated by Sijunzi decoction(SIJD)were cho-sen for contrast.Gastrointestinal electrical-automatic motili-ty were marked by chronically implanted electrodes and sens-ing element and compared between and after the treatment.RESULTS In the rat models of seven days ......