关键词: 骨形态发生蛋白;磷酸钙类;骨水泥;生物相容性材料

    摘 要:目的 将自行合成的磷酸钙骨水泥(CPC)作为载体与BMP复合成人工骨，检测其生物相容性. 方法 制备CPC/BMP及CPC骨块，通过体外实验、细胞培养、动物实验等方法观察其毒性、免疫原性、对血液系统的影响等生物相容性指标. 结果 动物实验表明材料属无毒级，不含致热原，体外试验不引起溶血反应，对凝血功能无明显影响.植入兔或小鼠肌袋内未检测出特异性抗体.组织学检查未见免疫排斥反应，对肌肉无刺激作用.对体外培养的细胞增殖没有明显抑制作用. 结论 材料有较好的生物相容性，临床使用安全.

    Biocompatibility of calcium phosphate cement/BMP composite as bone graft material

    SUN Ming-Lin，HU Yun-Yu，JIA Xin-Bing，LI Dan，LIU Zhong-Xiang，ZHU De-Sheng

    1 Institute of Orthopaedics of Chinese PLA，Xijing Hospital，3 Department of Parasitology，Faculty of Preclinical Medicine，4 Research Center of Laborato-ry Animal，Fourth Military Medical University，Xi'an710033，China，2 Second Hospital of Datong Mineral Bureau，Datong037003，China

    Keywords:bone morphogenetic protein;calcium phosphate;bone cement;biocompatibility materials

    Abstract:AIM To construct CPC/BMP composite by com-bining CPC with BMP，and to detect their biocompatibity.METHODS The toxicity，pyrogen，hemolytic activities and immunogen were detected by means of animal test，cell cul-ture，hemolysis test and histochemical technique.RESULTS The composites were found no toxicity and no pyrogen by an-imal test ......