Keywords:dopamine;form deprivation;rabbits;myopia;sonication;pathology

    Abstract:AIM To study effects of dopamine on form de-prived myopia.METHODS Fifty-two of seven-day-old neonatal rabbits were divided into group A，B and C and monocularly deprived of pattern vision by suturation of right eyelids.In group A(n=20)，no drug was used，while rab-bits in group B and C received a series of intravitreal injection of dopamine(n=16)or saline vehicle(n=16)with MD，re-spectively，the left eye were employed as control groups.An-terior chamber depth(ACD)，lenticular thickness(LT)，vit-reous chamber length(VCL)and axial length(AL)of each eye were determined by means of A-scan ultrasonography on day60，VCL/AL was calculated and pathologic changes were also observed.RESULTS VCL，AL and VCL/AL of de-prived eyes in group A and C were(7.9±0.6)mm，(15.4±0.6)mm，0.52±0.03;(7.3±0.5)mm，(15.1±0.7)mm，0.49±0.02;yet those of control eyes were(7.2±0.8)mm，(14.5±0.7)mm，0.48±0.02;(6.8±0.4)mm，(14.6±0.6)mm，0.46±0.02.VCL，AL and VCL/AL but not ACD and LT of deprived eyes showed a significant difference in group A and C(P<0.001) ......