关键词: 红花;色素类;药代动力学;分光光度法，紫外线

    摘 要:目的 对红花黄色素(SY)在小鼠体内的代谢、分布等药动学指标进行考察. 方法 红花黄色素在生物样品的浓度采用紫外可见分光光度法测定. 结果 小鼠尾静脉注射264.9mg·kg-1 红花黄色素(UV)后，血药浓度-时间曲线符合一室开放模型，曲线下面积(AUC)为57862.2μg·min·mL-1 ，半衰期(t1/2 )为41.6min，红花黄色素在肝和肾中浓度最高，心、脾和肺次之，脑中浓度最低. 结论 红花黄色素在小鼠体内分布广泛.

    Distributive character of safflor yellow in tissues of mice

    YANG Zhi-Fu WEN Ai-Dong JIANG Yong-Pei MEI Qi-Bing ZHANG San-Qi

    1 Department of Medicament，Xijing Hospital，

    2 Department of pharmacology，Faculty of Preclini-cal Medicine，Fourth Military Medical University，Xi'an710033，China

    Keywords:corthamus tinctorius;pigments pharma-cokinetics;spectrophotometry，ultraviolet

    Abstract:AIM To study the pharmacokinetical character of safflor yellow in mice.METHODS Ultraviolet(UV)assay was used to determine the safflor yellow concentration in bio-logical samples.RESULTS The concentration-time profiles of safflor yellow in mice after iv of264.9mg·kg

    -1 was shown to fit a single-compartment open model.AUC was57862.2μg·min·mL-1 ;t1/2 was41.6min.The highest level of safflor yellow was found in the liver and kidney ......