关键词: 眼高压;视网膜神经节细胞;双极细胞;川芎嗪;兔

    摘 要:目的 观察川芎嗪对慢性眼高压下视网膜神经细胞损伤的保护作用. 方法 用20g L-1 甲基纤维素前房注射法建立兔慢性眼高压模型.4组分别给予生理盐水、川芎嗪注射液10mg kg-1 ，2.5g L-1 噻吗心安眼液和联合应用川芎嗪与噻吗心安，连续用药4wk.于28d取眼球作光镜、电镜检查和光镜下细胞计数. 结果 生理盐水组模型眼节细胞数为(7.83±1.34)个/10格，双极细胞数为(10.66±1.63)个/格;川芎嗪组模型眼节细胞数为(9.50±3.87)个/10格，双极细胞数为(12.50±2.73)个/格;生理盐水组模型眼和川芎嗪组模型眼节细胞(P<0.05)与双极细胞(P<0.05)比较，有显著性差异.生理盐水组模型眼节细胞变性、坏死，锥、杆细胞外节紊乱，色素上皮不完整，川芎嗪组变化比生理盐水组轻，联合用药组变化最小. 结论 川芎嗪对慢性眼高压下视网膜神经节细胞和双极细胞具有保护作用.

    Protective effects of TMP on the retinal ganglions and bipolar cells of rabbits with elevated intraocular pressure

    SONG Zong-Ming CUI Shou-Xin ZHANG De-Xiu

    1 Department of Ophthalmology，Xijing Hospital，Fourth Military Medical University，Xi'an710033，China，

    2 First Hospital，Xi'an Jiaotong University，Xi'an710061，China

    Keywords:ocular hypertension;retinal ganglion cells;bipo-lar cell;tetramethylpyrazine;rabbits

    Abstract:AIM To observe the effects of tetram-ethylpyrazine(TMP)on the retinal ganglion and bipolar cells of rabbits with elevated intraocular pressure(IOP).METH┐ODS Elevated IOP was induced by20g L-1 methylcellulous injection into the anterior chamber.Normal saline ......