关键词: 血管成形术，经腔，经皮冠状动脉;支架;细胞间粘附分子;白细胞;流式细胞术

    摘 要:目的 研究不同类型PTCA及支架术后外周血白细胞粘附分子表达的变化. 方法 选择1999-10/2000-01我科住院行PTCA并即刻支架植入术的冠心病患者34例.以同期行冠状动脉造影的患者28例为对照组，分别于手术前后不同时间点采集股动脉血样，用FCM直接免疫荧光法检测股动脉血中性粒细胞、单核细胞和淋巴细胞表面粘附分子CD11b 表达水平. 结果 依据病变复杂程度分组，术前、术后1d3组白细胞表面粘附分子表达未见差别.TCL组与TBL组较TAL组术后2d和3d中性粒细胞与单核细胞表面CD11b 表达为高(2d P<0.05，3d P<0.05)，TCL与TBL两组无明显差异.术前、1d3组白细胞表面粘附分子表达未见差别.CGC组与CGB组术后2d和3d中性粒细胞与单核细胞表面CD11b 表达比CGA更为明显，CGC组比CGB组升高明显. 结论 PTCA及支架术可以激活中性粒细胞，导致中性粒细胞表面CD11b 表达的升高.PTCA及支架术后中性粒细胞表面CD11b 升高的程度可能能够作为手术损伤程度的间接指标.

    Clinical significance of the change of peripheral leu┐cocytes cell adhesion molecule CD 11b in different types of PTCA and stent implant

    LI Hu，JIA Guo-Liang，GUO Wen-Yi，LI Wei-Jie，LI Cheng-Xiang，LUAN Rong-Hua，CAO Yun-Xin

    1 Department of Cardiovasology，Xijing Hospital，Fourth Military Medical University，2 Central Labo-ratory，Faculty of Preclinical Medicine，Fourth Mil-itary Medical University，Xi'an710033，China

    Keywords:angioplasty，transluminal，percutaneous coro-nary;stents;cellular adhesion molecules;leuko-cytes;flowcytometry

    Abstract:AIM To observe changes of adhesion molecule of peripheral blood leucocytes.METHODS Femoral artery blood of34patients with PTCA and stents and28patients with coronary angiography were selected at deferent time points.Expression of CD ......