关键词: 冠心病;低密度脂蛋白;血脂

    摘 要:目的 观察冠心病患者血浆小而密低密度脂蛋白(sLDL)和其他脂类成分的变化及相互关系. 方法 采用一次性密度梯度超速离心法及聚丙烯酰胺凝胶电泳法，分离、测定102例冠心病患者和72例对照者血浆sLDL，同时测定血浆总胆固醇(TC)、三酰甘油(TG)等. 结果 ①冠心病组sLDL占总低密度脂蛋白(LDL)的(40.6±14.7)%，高于对照组(18.6±8.9)%(P<0.05);冠心病患者LDL中TG，TG/TC比值升高，LDL分布向小而密的亚组分倾移;②sLDL增多患者的TG水平明显高于sLDL正常者(P<0.01). 结论 sLDL与冠心病发生发展有关，且与TG关系密切;sLDL测定可作为预测冠心病发病危险的指标.

    Clinical study of small，dense low┐density lipopro┐tein in patients with coronary heart disease

    ZHANG Jun，LI Lan-Sun，JIA Guo-Liang

    Department of Cardiovasology，Xijing Hospital，Fourth Military Medical University，Xi'an710033，China

    Keywords:coronary disease;LDL;lipid

    Abstract:AIM To observe the relationship and change of small，dense low density lipoprotein(sLDL)and other lipids from plasma of patients with coronary heart disease.METH┐ODS sLDL subfractions were seperated directly from plas-ma by density gradient ultracentrifugation.The subfraction distributions were observed by poly-acrylamide gel elec-trophoresis ......