【摘要】 目的 探讨急性冠脉综合征(ACS)患者同型半胱氨酸(Hcy)的水平，以及Hcy与炎症因素的相关性。方法 74例ACS患者其中急性心肌梗死(AMI)34例，不稳定型心绞痛(UA)40例；另设性别、年龄相匹配经冠脉造影阴性排除冠心病的对照组33例。采取高效液相色谱分析法测定血浆中的Hcy,同时测定血浆中的血糖、血脂和血C反应蛋白(CRP)。结果 (1)AMI患者的血浆Hcy浓度(17.21±4.43)μmol/L明显高于对照组(8.99±3.75)μmol/L (P<0.05)；UA患者Hcy浓度(15.66±5.24)μmol/L明显高于对照组(8.99±3.75)μmol/L (P<0.05)；AMI组与UA组无明显差异；(2)ACS患者Hcy与CRP水平呈正相关(r=0.59)。结论 高Hcy血症是急性冠脉综合征的一个独立危险因子，而且与引起急性冠脉综合征相关的炎症反应呈正相关。

    【关键词】 急性冠脉综合征; 同型半胱氨酸 ; C-反应蛋白

    Level of homocysteine in acute coronary syndrome and its correlation with inflammation

    FAN Xiao-jun ,ZHU Zheng-biao,SUN Hong-ying.

    Department of Cardiology,People’s Hospital of Jianli,Hubei 433300，China

    【Abstract】 Objective To investigate the level of homocysteine(Hcy) in acute coronary syndrome(ACS) and its correlation with inflammation. Methods 74 ASC patients,34 cases of AMI and 40 cases of UA,33 sex- and age-matched controls angiography of which was negative. All cases were recorded including diabetes,hypertension,mass index and so on . Plasma Hcy was determined by high-pressure liquid chromatography. Meanwhile,lipid and C-reactive protein(CRP) were also determined . Results (1) The level of AMI was higher[(17.21±4.43)μmo1/L] than controls[(8.99±3.75)μmo1/L] (P<0.05). The level of UA was higher[(15.66±5.24)μmo1/L]than controls[(8.99±3.75)μmo1/L](P<0.05).There was no significant difference between AMI and UA. (2) The level of homocysteine in ACS had positive correlation with CRP. Conclusion Hyperhomocysteine is an independent risk factor in ACS ,and with positive correlation with CRP. ......