【摘要】 目的 探讨超声介导腹腔神经节毁损对胰腺癌疼痛患者的治疗作用。方法 97例胰腺癌疼痛患者采用B超引导经皮穿刺，于腹腔动脉干根部旁侧注入无水乙醇15ml，实施腹腔神经节化学性毁损。对比观察治疗前后疼痛的视觉模拟评分(VAS)、血清SP和β-EP以及T细胞亚群水平变化。结果 97例中仅1例穿刺失败，成功率99.0%，无严重并发症；VAS、血清SP和β-EP与术前比较差异有显著性(P<0.01，P<0.05，P<0.01)；疼痛完全缓解率54.2%，部分缓解率21.9%，轻度缓解率11.4%，无效12.5%，疼痛复发率仅10.7%，生存质量明显提高；与疼痛治疗前相比，胰腺癌疼痛患者的淋巴细胞T亚群水平显著上升(P<0.01)。结论 本微创技术具有很高的安全性，能显著减轻胰腺癌性疼痛并提高细胞免疫水平。

    【关键词】 超声介入；疼痛治疗；胰腺癌；腹腔神经节

    Analgesia on pancreatic carcinoma with destruction of celiac ganglion by ultrasound intervention

    WANG Tao,TIAN Fu-zhou,CAI Zhong-hong,et al.

    Department of General Surgery,Hospital of Chengdu Military District,Chengdu 610083,China

    【Abstract】 Objective To detect the therapeutic effects of destruction of celiac ganglion on patients with pancreatic carcinoma with intractable pain.Methods 97 cases with advanced pancreatic carcinoma accepted splanchna destruction 15ml pure alcohol injection around celiac ganglion by ultrasound intervention.The varieties of VAS,serum SP、β-EP and T-lymphocyte subtypes level were compared between pre-therapy and post-therapy.Results Successful rate of puncture was 99.0%,with 1 loss.No serious complications such as acute pancreatitis,pancreatic fistula,bleeding or celiac infection in our study.VAS,serum SP level and β-EP level significantly changed after treatment (P<0.01 ......