白介素1α_

IL1α和MMP9在中耳胆脂瘤上皮中的表达

http://www.100md.com 《西安交通大学学报》 2005年第5期

白介素1α,,白介素1α；基质金属蛋白酶9；中耳；,胆脂瘤,1材料与方法,2结果,3讨论,参考文献

     摘要：目的研究白介素1α(interleukin1α, IL1α)和基质金属蛋白酶9(matrix metalloproteinase9, MMP9)的表达，探讨二者与胆脂瘤侵袭破坏能力的关系。方法采用免疫组织化学SP法检测了IL1α、MMP9在21例后天继发性胆脂瘤上皮与10例胆脂瘤患者外耳道皮肤表皮中的表达。结果 IL1α和MMP9在胆脂瘤上皮的阳性表达率明显高于外耳道皮肤表皮，差异具显著性(P<0.01, P<0.01)；胆脂瘤上皮IL1α、MMP9表达均与胆脂瘤的侵袭破坏程度正相关(P<0.05，P<0.05)；胆脂瘤上皮中IL1α、MMP9表达存在正相关性。结论 IL1α、MMP9是介导胆脂瘤侵袭破坏行为的重要细胞因子。在体内IL1α可能对MMP9表达具有上调作用。

    关键词：白介素1α；基质金属蛋白酶9；中耳；胆脂瘤

    The expression of interleukin1α and matrix metalloproteinase9 in middle ear cholesteatoma

    Wei Junrong, Ren Xiaoyong, Zheng Guoxi

    (Department of Otorhinolarynology, Second Hospital of Xian Jiaotong University, Xian 710004, China)

    ABSTRACT：Objective To explore the effects of interleukin1α (IL1α) and matrix metalloproteinase9(MMP9) in middle ear cholesteatoma and to explore the correlation between their expression and the ability of destruction of cholesteatoma. Methods IL1α and MMP9 were determined immunohistochemically in the specimens from 21 cases cholesteatomas and 10 external ear skin of patients with cholesteatoma. Results The positive expression of IL1α and MMP9 in cholesteatoma epithelialium were increased greatly than that in external epidermis (P<0.01). Statistical analysis showed that the agressive ability of cholesteatoma was significantly positively related to the expression of IL1α and MMP9 in cholesteatoma epithelialium(P<0.05). Conclusion IL1α and MMP9 are important factors in inducing bone destruction of cholesteatoma. IL1α maybe play a role in upregulating MMP9 expression in middle ear cholesteatoma. ......

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