Protective effects of Qidantongmai tablet on myocardial mitochondrion injury in rats

    WANG Zongª²Ren, MA Jing, HANG Ling, MA Shinª²Pin, CHEN Xiaoª²Li, FAN Aiª²Ling, LI Jinª²Hua, XIAO Tieª²Hui, ZHENG Jin

    Department of Traditional Chinese Medicine, Department of Pharmaceutics, Department of Clinical Examination, Xijing Hospital, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To study the protective effects of Qidantongmai tablet (QDTMT) on the injury of myocardial mitochondrion induced by isoproterenol. METHODS: Rats were fed with QDTMT(2 g¡¤kg-1)for two weeks and acute myocardial ischemia was induced by subcutaneous injection of isoproterenol (ISP. 5 mg¡¤kg-1) into rats. The content of MDA and the activity of SOD, GSHª²PX and SDH in myocardial mitochondrion were measured. RESULTS: In the model group, the content of MDA increased and the activity of SOD decreased significantly. Compared with those in the model group, the MDA content of mitochondrion reduced in the QDTMT group and the activity of SOD, GSHª²PX and SDH increased significantly [( 8.9¡À0.6 0) vs (5.5¡À0.6) ¦Ìmol¡¤ g-1, (673.2¡À25.2 ) vs (536.2¡À20.3) kNU¡¤ g-1, (55.3¡À6.0) vs (40.7¡À7.1) kU¡¤g-1, (0.07¡À0.01) vs (0.05¡À0.01) kat¡¤g-1 , P<0.01). CONCLUSION: QDTMT can alleviate the injury caused by oxygen free radicals to myocardial mitochondrion by decreasing the content of MDA and increasing the activity of SOD, GSHª²PX and SDH in myocardial mitochondrion. ......