【摘要】 朊蛋白(prion protein，PrP)是一种能在动物和人类中引起多种中枢神经系统变性疾病的传染性蛋白颗粒，疾病型PrP是PrPC的同质异构体，称为PrPSC，这是真正意义的致病物质，也称为朊病毒。因其主要侵犯大脑，不发病无法实施治疗，一旦发病为时已晚，所以人类朊蛋白疾病很可能是21世纪医学界最棘手的问题之一。

    【关键词】 朊蛋白；早老性痴呆；朊病毒

    【Abstract】 The albumen of protein (prion protein, PrP) is a kind of infective albumen particle that can cause the degeneration disease of many kinds of central nervous system among the animal and the mankind, disease-specific type PrP is the homogeneity of PrPC called PrPSC. This is a pathogenic material in a real meaning, called the prion virus too.Because it infringes the brain mainly, and unable unable to be detected untill illness have come on,when it is late to treat,human protein albumen disease is possible to become a difficult problem in the 21th medical century.

    【Key words】 prion protein(PrP)；Creutz feldt-Jarob disease (CJD)；scrapie prion protein(PrPSC)

    美国神经生物学和生物化学家Stanley B Prusiner发现Prion蛋白 ......