国人肿瘤坏死因子的基因多态性与 H pylori 感染无相关性
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李 岚, 夏 冰, 李 春
肿瘤坏死因子-a;淋巴毒素-a;幽门螺杆菌;基因多态性李岚,夏冰,李春.国人肿瘤坏死因子的基因多态性与Hpylori感染无相关性. 世界华人消化杂志2006;14(3)287-292
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李岚,夏冰, 李春, 武汉大学医学院中南医院综合医疗科、消化疾病研究中心, 武汉大学医学院过敏与免疫相关疾病重点实验室 湖北省武汉市 430071
李岚,女, 1980-12-31生,贵州省天柱县人, 苗族, 武汉大学医学院综合医疗科在读硕士研究生, 主要从事胃肠疾病的免疫遗传学机制研究.
湖北省自然科学基金资助项目, No.2000J047
通讯作者: 夏冰, 430071, 湖北省武汉市东湖路169号, 武汉大学中南医院综合医疗科. bingxia2004@yahoo.com.cn
电话:027-67812985-2985 传真: 027-87330795
收稿日期:2005-11-15 接受日期:2005-11-24
No Association between polymorphism of tumor necrosis factor gene and helicobacter pylori infection in Han Chinese in central China
Lan Li, Bing Xia, Chun Li
Lan Li, Bing Xia, Chun Li, Department of Internal Medicine and Geriatrics, Research Center of Digestive Diseases, Zhongnan Hospital; Key Lab of Allergy and Immune-Related Diseases, Wuhan University School of Medicine, Wuhan 430071, Hubei Province, China
Supported by the Natural Science Foundation of Hubei Province, No. 2000J047
Correspondence to: Dr. Bing Xia, Department of Internal Medicine and Geriatrics, Zhongnan Hospital, Wuhan University School of Medicine, 169 Donghu Road, Wuhan 430071, Hubei Province, China. bingxia2004@yahoo.com.cn
Received: 2005-11-15 Accepted: 2005-11-24
Abstract
AIM:To investigate the association of gene polymorphism of tumor necrosis factor-alpha (TNF-a) 308, lymphotoxin-alpha (LT-a) with H pylori infection in Han Chinese in central China.
METHODS: Specific polymerase chain reaction and restriction fragment length polymorphism (RFLP) were used to detect the genotypes of leukocyte genome DNA, TNF-a 308 and LT-a gene in the peripheral blood of 264 healthy volunteers from Wuhan, China. H pylori infection status was determined by a validated serological test.
RESULTS: The positive rate of H pylori infection was 62.1%(164/264) in the healthy volunteers. There was no significant difference in allele frequencies of TNF-a 308, LT-a AspHⅠ, and LT-a NcoⅠ between H pylori positive and negative group ......
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