乙肝病毒外膜大蛋白检测对于判定HBV DNA复制的意义
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孙 颖, 辛绍杰, 雷 厉, 侯 俊, 貌盼勇
乙肝病毒包膜大蛋白;乙肝病毒DNA;乙肝病毒标志物孙颖,辛绍杰,雷厉,侯俊,貌盼勇.乙肝病毒外膜大蛋白检测对于判定HBVDNA复制的意义.世界华人消化杂志2006;14(3)354-3570引言HBV
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孙颖, 解放军军医进修学院 北京市 100853
辛绍杰, 雷厉, 侯俊, 貌盼勇, 解放军302医院传染病研究所病毒研究室 北京市 100039
通讯作者:貌盼勇, 100039, 北京市西四环中路100号, 解放军302医院传染病研究所病毒研究室. maopy302@yahoo.com.cn
共同通讯作者:辛绍杰
电话: 010-66933315 传真: 010-63831874
收稿日期: 2005-11-08 接受日期: 2005-12-17
Significance of hepatitis B virus large protein detection in prediction of HBV DNA replication
Ying Sun, Shao-Jie Xin, Li Lei, Jun Hou, Pan-Yong Mao
Ying Sun,Postgraduate Medical School of Chinese PLA, Beijing 100853, China
Shao-Jie Xin, Li Lei, Jun Hou, Pan-Yong Mao, Department of Virology, Institute of Infectious Disease, 302 Hospital of Chinese PLA, Beijing 100039, China
correspondence to: Pan-Yong Mao, the Department of Virology, Institute of Infectious Diseases, 302 Hospital of Chinese PLA, Beijing 100039, China. maopy302@yahoo.com.cn
Co-correspondence to: Shao-Jie Xin
Received: 2005-11-08 Accepted:2005-12-17
Abstract
AIM: To explore the significance of hepatitis V virus large protein (HBV-LP) in the diagnosis of viral replication.
METHODS: Serum HBV DNA level was quantitatively detected using real-time polymerase chain reaction, and HBV-LP, Pre-S1 and HBV markers expression were measured by enzyme-linked immunosorbent assay (ELISA) in 254 cases of infected serum.
RESULTS: There was no significant difference between the levels of HBV DNA and HBV-LP (P >0.05). The expression of HBV DNA and HBV-LP were not significantly different among various patterns of HBV serological markers, either (P >0 ......
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