【摘要】 组织因子途径抑制物(TFPI)是组织因子、Ⅶ因子和Ⅹ因子的天然抑制物，在维持正常凝血中发挥关键的生理作用。近年来，随着对TFPI结构与功能研究的深化，发现它还能抗炎症和诱导凋亡，并在动脉粥样硬化、败血症和恶性肿瘤等疾病的治疗上有重要的应用价值。本文将对TFPI的生理作用和临床应用前景进行综述。

    【关键词】 组织因子途径抑制物；结构；功能；生理作用；临床应用

    Physiological functions and applications of tissue factor pathway inhibitor

    LIANG Wang，MA Duan.

    The Key Laboratory of Molecular Medicine，Ministry of Education，Shanghai Medical College，Fudan University， Shanghai 200032，China

    【Abstract】 Tissue factor pathway inhibitor (TFPI)，the inherent inhibitor of tissue factor (TF) and factors Ⅶ and Ⅹ，is a key molecule that plays a regulatory role in the physiological coagulation.People’s knowledge on its structure and functions has been intensively enlarged in recent years.Besides the functions of anti-inflammation and introducing apoptosis，it was also found that TFPI could be served as medicine in treating some diseases such as atherosclerosis，sepsis and malignancy.This paper is a review mainly on the physiological functions and applications of TFPI.

    【Key words】 TFPI; structure; function; physiological effect; application

    组织因子途径抑制物(tissue factor pathway inhibitor ......