Active immunization could treat recurrent hum
A research project conducted by Dr. Zhang Ju, director of the army gene diagnosis research institute, the Fourth Military Medical University proved that active immunity therapy by mainly using antigen sensitized and activated dendritic cells demonstrated remarkable effect for the treatment of condyloma acuminata of the genital organs caused by recurrent infection with human papilloma virus. This achievement established a new pathway for the clinical treatment of human papilloma virus infection.
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Dr. Zhang Ju classified 39 recurrent cases of persistent condyloma acuminata into two groups for controlled study. The treatment group consisted of 19 cases (9 male and 10 female) with a mean age of 26, and an average course of illness 12±3 months. The control group consisted of 20 cases (8 male and 12 female), with an average age of 27 and a mean course of illness of 13±4 months. During the treatment, active immunotherapy was adopted for the treatment group. The antigen was extracted from the verruca tissue, and 10-20 ml of the peripheral blood of the patient was used for the extraction of mononuclear cells for the culture of dendritic cells. After induction, activation and sensitization of the antigen, subcutaneous injection was done at the diseased area once a week for a period of one month. In the controls, recombinant interferon therapy was carried out, by systemic administration of 1-3 million U/d and at the same time injections of antiviral drugs were given for a period of one month. Follow-up of half year showed that in the treatment group of 19 cases, 16 had no recurrence accounting for 80 % and the 3 cases with recurrence occurred in an average of 4 weeks. In the controls, 6 cases among the 20 had no recurrence, accounting for 30 %. The 14 cases with recurrence occurred in a mean period of 7 days. There was significant difference in the periods of recurrence (P<0.05). PCR detection was used one month after the treatment; in the treatment group 11 cases had negative conversion of DIV-A and in the controls 4 cases had negative conversion, indicating a better treatment effect in the active immunotherapy group. The researchers considered that this method using autologous cells of the patients and verruca tissue as the effector cells and antigen, not only played an important role in the conversion of human papilloma virus infection, but also improved the immune function of the patients, eliminated the virus, improved the treatment results with less side effects. Its cost was low and was an ideal method of treatment., 百拇医药
, http://www.100md.com
Dr. Zhang Ju classified 39 recurrent cases of persistent condyloma acuminata into two groups for controlled study. The treatment group consisted of 19 cases (9 male and 10 female) with a mean age of 26, and an average course of illness 12±3 months. The control group consisted of 20 cases (8 male and 12 female), with an average age of 27 and a mean course of illness of 13±4 months. During the treatment, active immunotherapy was adopted for the treatment group. The antigen was extracted from the verruca tissue, and 10-20 ml of the peripheral blood of the patient was used for the extraction of mononuclear cells for the culture of dendritic cells. After induction, activation and sensitization of the antigen, subcutaneous injection was done at the diseased area once a week for a period of one month. In the controls, recombinant interferon therapy was carried out, by systemic administration of 1-3 million U/d and at the same time injections of antiviral drugs were given for a period of one month. Follow-up of half year showed that in the treatment group of 19 cases, 16 had no recurrence accounting for 80 % and the 3 cases with recurrence occurred in an average of 4 weeks. In the controls, 6 cases among the 20 had no recurrence, accounting for 30 %. The 14 cases with recurrence occurred in a mean period of 7 days. There was significant difference in the periods of recurrence (P<0.05). PCR detection was used one month after the treatment; in the treatment group 11 cases had negative conversion of DIV-A and in the controls 4 cases had negative conversion, indicating a better treatment effect in the active immunotherapy group. The researchers considered that this method using autologous cells of the patients and verruca tissue as the effector cells and antigen, not only played an important role in the conversion of human papilloma virus infection, but also improved the immune function of the patients, eliminated the virus, improved the treatment results with less side effects. Its cost was low and was an ideal method of treatment., 百拇医药