Persistent peritoneal washing chemotherapy improve
"Experimental and clinical study of continuous abdominal cavity irritation with chemotherapy for the treatment of ovarian cancer", a designed project of the scientific committee of Shandong province and assumed the responsibility by Professor Yang Chunsheng, doctorate tutor of the department of Obs and Gyn, Shandong provincial hospital, passed the evaluation recently.
On the basis of animal experimental study, they randomly allocated the in-patients into the routine group (15 cases) and the irrigation group (14 cases), and started the systemic PAC regime of chemotherapy chiefly with abdominal administration of cisplatin. The results revealed that in the aspects of pharmacokinetics, the concentration of cisplatin both in the serum and the abdominal fluid was higher than that in the routine group, the AUC of the time-concentration curve was remarkably larger than that of the routine group without evident increase of the toxic side effects. In the short term effectiveness, the Ca125 decreased from 246.7 KU/l prior to chemotherapy to 56.4 KU/L, the rate of complete remission (CR) plus partial remission (PR) was 56 %, which was remarkably higher than that of routine group
(20 %) (P<0.05).
The researchers considered that continuous abdominal cavity irrigation chemotherapy resulted in a remarkably higher concentration of cisplatin in the serum and abdominal fluid and a short-term effectiveness notably superior to that of the routine abdominal chemotherapy., http://www.100md.com
On the basis of animal experimental study, they randomly allocated the in-patients into the routine group (15 cases) and the irrigation group (14 cases), and started the systemic PAC regime of chemotherapy chiefly with abdominal administration of cisplatin. The results revealed that in the aspects of pharmacokinetics, the concentration of cisplatin both in the serum and the abdominal fluid was higher than that in the routine group, the AUC of the time-concentration curve was remarkably larger than that of the routine group without evident increase of the toxic side effects. In the short term effectiveness, the Ca125 decreased from 246.7 KU/l prior to chemotherapy to 56.4 KU/L, the rate of complete remission (CR) plus partial remission (PR) was 56 %, which was remarkably higher than that of routine group
(20 %) (P<0.05).
The researchers considered that continuous abdominal cavity irrigation chemotherapy resulted in a remarkably higher concentration of cisplatin in the serum and abdominal fluid and a short-term effectiveness notably superior to that of the routine abdominal chemotherapy., http://www.100md.com