昆明白族儿童幽门螺杆菌感染与HLA-DQA1等位基因的相关性
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王美芬, 黄永坤, 郝 萍, 戚 勤, 文革生,
白族儿童;幽门螺杆菌;HLA-DQA1,王美芬,黄永坤,戚勤,文革生,李海林,周丽芳,郝萍,通讯作者:,Associationbetw
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王美芬, 黄永坤, 戚勤, 文革生, 李海林, 周丽芳, 昆明医学院第一附属医院儿科 云南省昆明市 650032
郝萍, 昆明医学院第一附属医院临床医学实验中心 云南省昆明市 650032
云南省教育厅重点项目基金, No. 04Z065C
通讯作者: 黄永坤, 650032, 云南省昆明市西昌路295号, 昆明医学院第一附属医院儿科. hykkmyncn@hotmail.com
收稿日期: 2005-12-08 接受日期: 2005-12-31
Association between HLA-DQA1 alleles and H pylori infection in Bai-ethnic children from Kunming
Mei-Fen Wang, Yong-Kun Huang, Ping Hao, Qin Qi, Ge-Sheng Wen, Hai-Lin Li, Li-Fang Zhou
Mei-Fen Wang, Yong-Kun Huang, Qin Qi, Ge-Sheng Wen, Hai-Lin Li, Li-Fang Zhou, Department of Pediatrics, the Fisrt Affiliated Hospital of Kunming Medical College, Kunming 650032, Yunnan Province, China
Ping Hao, Experimental Center of Clinical Medicine, the First Affiliated Hospital of Kunming Medical College, Kunming 650032, Yunnan Province, China
Supported by the Key Project of Education Department of Yunnan Province, No. 04Z065C
correspondence to: Dr. Yong-Kun Huang, Department of Pediatrics, the First Affiliated Hospital, 295 Xichang Road, Kunming Medical College, Kunming 650032, Yunnan Province, China. hykkmyncn@hotmail.com
Received: 2005-12-08 Accepted: 2005-12-31
Abstract
AIM: To find the susceptible or resistant genes of H pylori infection in Bai-ethnic children of Kunming, and to explore the immunogenetic mechanism of H pylori infection.
METHODS: Polymerase chain reaction-sequence specific primers (PCR-SSP) technique was used to detect the allelic distribution of HLA-DQA1 in Bai-ethnic children with or without H pylori infection (n = 32, 34, respectively) from Kunming. H pylori infection was identified by combination of dot-immunogold filtration assay and immunobloting technique.
RESULTS: The allelic frequency of HLA-DQA1 *010401 or *0402 was significantly lower in children with H pylori infection than that in children without H pylori infection (0 vs 15%, χ2 = 0, P = 0 ......
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