骨髓间充质干细胞在胰腺生理更新和病理再生中的作用
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江学良, 李兆申, 崔慧斐
骨髓间充质干细胞;胰腺干细胞;胰腺炎,江学良,李兆申,崔慧斐,江学良,通讯作者:,Roleofbonemarrowmesenchymalstem
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江学良, 李兆申, 中国人民解放军第二军医大学长海医院消化科 上海市 200433
崔慧斐, 山东大学药学院 山东省济南市 250014
江学良, 男, 1967-08-26生, 山东省潍坊人, 汉族, 医学博士, 主编《溃疡性结肠炎》和《溃疡性结肠炎现代诊疗手册》, 副主编专著2部,《世界华人消化杂志》等8家杂志共同主编和常务编委. 主要研究方向为溃疡性结肠炎和消化内镜, 获军队及省部级科技成果奖6项.
通讯作者: 李兆申, 200433, 上海市长海路174号, 第二军医大学长海医院消化科. jiangxueliang678@126.com
电话: 021-65573144
收稿日期: 2005-12-01 接受日期: 2005-12-24
Role of bone marrow mesenchymal stem cells in pancreas self-restoration and pathological regeneration
Xue-Liang Jiang, Zhao-Shen Li, Hui-Fei Cui
Xue-Liang Jiang, Zhao-Shen Li, Department of Gastroenterology, Changhai Hospital of the Second Military Medical University, Shanghai 200433, China
Hui-Fei Cui, College of Pharmacy, Shandong University, Jinan 250012, Shandong Province, China
Correspondence to: Zhao-Shen Li, Department of Gastroenterology, Changhai Hospital of the Second Military Medical University, Shanghai 200433, China. jiangxueliang678@126.com
Received: 2005-12-01 Accepted: 2005-12-24
Abstract
AIM: To investigate the role of bone marrow mesenchymal stem cells (MSC) in pancreatic self-restoration and pathological regeneration.
METHODS: Sixty Sprague-Dawley (SD) rats were randomly assigned into 5 groups (n = 12). Group A acted as the normal negative control without any treatment, and group B received labeled autologous bone marrow MSC only. Group C was induced mild acute pancreatitis by subcutaneous injection of caerulein 20 mg/(kg·h) 4 times, and group D was induced severe acute pancreatitis by intraperitoneal injection of L-arginine (2 g/kg) twice. Group E was the stem cell mobilized group treated by injection of granulocyte-colony stimulating factor (G-CSF) into rats for 3 d at a dose of 40 mg/(kg·d) 3 d before the induction of SAP. MSC were stained with Hoechst33258 and transplanted into their original cavity. Two and eight weeks after transplantation, the rats were sacrificed, and pancreatic tissues were harvested ......
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