丹酚酸B对MDA刺激的肝星状细胞增殖的抑制作用
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王晓玲, 刘 平, 崔云华, 胡旭东, 李伯勤,
丹酚酸B;肝星状细胞;增殖周期;丙二醛王晓玲,刘平,崔云华,胡旭东,李伯勤,应馨萍.丹酚酸B对MDA刺激的肝星状细胞增殖的抑制作用. 世界华人消化杂志2006;14(5)476-480,丹
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王晓玲, 胡旭东, 上海中医药大学生物教研室 上海市 201203
刘平, 上海中医药大学肝病研究所 上海市 201203
崔云华, 上海中医药大学针灸经络研究所 上海市 201203
李伯勤, 应馨萍, 上海中医药大学教学实验中心 上海市 201203
王晓玲, 女, 1967-12-21生, 河南省修武县人, 汉族, 1998年上海中医药大学博士, 主要从事肝纤维化发生的细胞生物学研究.
国家自然科学基金青年基金资助项目, No. 30000230
通讯作者: 王晓玲, 201203, 上海市浦东张江蔡伦路1200号, 上海中医药大学生物教研室. wxlzzx@sohu.com
电话: 021-51322124
收稿日期: 2005-12-08 接受日期: 2005-12-19
Inhibitory effect of salvianolic acid B on malondialdehyde-stimulated proliferation of rat hepatic stellate cells in vitro
Xiao-Ling Wang, Ping Liu, Yun-Hua Cui, Xu-Dong Hu, Bo-Qin Li, Xin-Ping Ying
Xiao-Ling Wang, Xu-Dong Hu, Department of Biology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Ping Liu, Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Yun-Hua Cui, Institute of Acupuncture and Moxibustion, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Bo-Qin Li, Xin-Ping Ying, Center of Laboratory, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Supported by National Natural Science Foundation for the Youth of China, No. 30000230
Correspondence to: Dr. Xiao-Ling Wang, Department of Biology, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203,
China. wxlzzx@sohu.com
Received: 2005-12-08 Accepted: 2005-12-19
Abstract
AIM: To investigate the inhibitory effects of salvianolic acid B (SAB) on the proliferation of rat hepatic stellate cells stimulated by malondial-dehyde (MDA).
METHODS:Hepatic stellate cells were derived from normal rat by in situ perfusion, digestion and density gradient centrifugation with 108 g/L Nycodenz. Then the cells were stimulated by MDA (200 mmol/L) for 2 h, and then treated with various concentrations of SAB (1 and 10 mmol/L). The proliferation of cells was assayed by MTT incorporation, and the level of intracellular oxidation was reflected by 2', 7'-dichlorodihydrofluorescein (DCFH) ......
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