光动力治疗食道癌近期疗效观察
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潘林娜, 张志燕, 李 曼, 苏蓉玲
光动力学疗法;食道癌;疗效;生活质量,潘林娜,张志燕,李曼,苏蓉玲,通讯作者:,Effectofphotodynamictherapyforesophagealcarc
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潘林娜, 张志燕, 李曼, 苏蓉玲, 哈尔滨医科大学附属肿瘤医院腔镜室 黑龙江省哈尔滨市 150040
通讯作者: 潘林娜, 150040, 黑龙江省哈尔滨市南岗区哈平路150号, 哈尔滨医科大学附属肿瘤医院腔镜室. limanl2488@hotmail.com
电话: 0451-82081615 传真: 0451-86663760
收稿日期: 2005-11-08 接受日期: 2005-12-02
Effect of photodynamic therapy for esophageal carcinoma in near future
Lin-Na Pan, Zhi-Yan Zhang, Man Li, Rong-ling Su
Lin-Na Pan, Zhi-Yan Zhang, Man Li, Rong-Ling Su, the Affilated Cancer Hospital of Harbin Medical University, Harbin 150040, Heilongjiang Province, China
Correspondence to: Lin-Na Pan, the Affilated Cancer Hospital of Harbin Medical University, Harbin 150040, Heilongjiang Province, China. limanl2488@hotmail.com
Received: 2005-11-08 Accepted: 2005-12-02
Abstract
AIM: To discuss the clinical efficacy and effect of photofrin photodynamic therapy (PDT) in treatment of patients with esophageal carci-noma.
METHODS: Twenty-six esophageal carcinoma patients treated with conservative method were involved in this study. All patients were then treated with PDT under endoscope. Endoscopy was performed to determine the tumor response to PDT. The patients were followed up by WHOQOL-BREF to investigate the quality of life (QOL) and the survival time of patients as well as the side effect of PDT.
RESULTS: The total rate of effective PDT was 76.9%(20/26), and patients whose clinical symptoms alleviated covered a percentage of 80.8%(21/26). The half-year survival rate for the patients was 73.1%(19/26). The QOL of patients was significantly improved in physiological and psychological domains 3 mo after PDT (F = 4.827, P < 0.05).
CONCLUSION: PDT is effective and safe in the treatment of middle- or late-stage esophageal carcinoma.
Key Words: Photochemotherapy; Esophageal carcinoma; Clinical efficacy; Quality of life
Pan LN, Zhang ZY, Li M, Su RL ......
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