NF-κB对肠缺血再灌注肝损伤P-选择素表达和中性粒细胞浸润的作用
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李英华, 田晓峰, 王真真, 张雪松, 张 峰,
肝损伤;肠缺血再灌注;核转录因子kB;P-选择素李英华,田晓峰,王真真,张雪松,张峰,金松,姚继红.NF-kB对肠缺血再灌注肝损伤P-选择素表达和中性粒细胞浸润的作用. 世界华人消化杂志2
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李英华, 田晓峰,张雪松, 大连医科大学附属第二医院普外科辽宁省大连市 116023
王真真, 张峰,金松, 姚继红,大连医科大学药理教研室 辽宁省大连市 116027
李英华, 女, 1976-03-27, 吉林省通化市人, 2005年大连医科大学硕士毕业,现为大连医科大学附属第二医院肿瘤科住院医师.
辽宁省科学技术厅自然科学基金资助项目, No. 20042135
通讯作者: 姚继红, 大连市沙河口区中山路465号, 大连医科大学药理教研室, yaojihong65@tom.com
电话: 0411-84720229 传真: 0411-84720031
收稿日期: 2005-11-09 接受日期:2005-11-24
Effect of nuclear factor-kB on P-selectin expression and neutrophil infiltration in liver injury induced by intestinal ischemia/reperfusion in rats
Ying-Hua Li, Xiao-Feng Tian, Zhen-Zhen Wang, Xue-Song Zhang, Feng Zhang, Song Jin, Ji-Hong Yao
Ying-Hua Li, Xiao-Feng Tian, Xue-Song Zhang, Department of General Surgery, the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China
Zhen-Zhen Wang, Feng Zhang, Song Jin, Ji-Hong Yao, Department of Pharmacology, Dalian Medical University, Dalian 116027, Liaoning Province, China
Supported by Natural Science Foundation of Liaoning Province, No. 20042135
Correspondence to: Ji-Hong Yao, Department of Pharmacology, Dalian Medical University, 465 Zhongshan Road, Dalian 116027, Liaoning Province,
China. yaojihong65@tom.com
Received: 2005-11-09 Accepted: 2005-11-24
Abstract
AIM: To investigate the effect of nuclear factor-kB (NF-kB)on P-selectin expression and neutro-phil accumulation in liver injury induced by intestinal ischemia/reperfusion (I/R) in rats.
METHODS: Twenty-four Wistar rats were randomly assigned into sham operation (control, n = 8), intestinal I/R (n = 8), and pyrrolidine dithiocarbamate (PDTC) treatment (n = 8). The rats in I/R and PDTC group received 1 h SMA occlusion and 2 h reperfusion, and those in PDTC group was also intraperitoneally injected with 20 g/L PDTC (100 mg/kg) 1 h before operation. Liver histology was observed under light microscope. The level of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and interleukin-6 (IL-6), and liver tissue superoxide dismutase (SOD), myeloperoxidase (MPO) contents were measured ......
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