【摘要】 目的 研究肝硬化患者胃半固体排空功能及其与血清NO水平关系。方法 应用放射学方法对33例肝硬化患者(Child-Pugh A级10例，B级17例，C级6例)和14例健康志愿者的胃半固体排空时间进行测定，并测定其空腹血清NO浓度。结果 肝硬化患者进食10mm小钡条和标准餐混合物后胃半固体排空时间为(6.38±1.1)h，血清NO浓度为(66.46±11.96)μmol/L；健康对照组则分别为(4.94±1.87)h和(50.23±9.7)μmol/L,差异均有显著性。而Child A,B,C 3组之间无差别。结论 肝硬化患者半固体排空时间延迟，NO在动力延缓中起着重要的作用。放射学方法简单准确。

    【关键词】 胃半固体排空；肝硬化；一氧化氮；钡条

    The primary study for the relationship between gastric semi-solid emptying and serum NO in patients with liver cirrhosis

    XIANG Dan-ni,CAO Xiu-ying，LIANG Jun-yan,et al.

    Department of Digestive Disease,Huadong Hospital,Shanghai 200040,China

    【Abstract】 Objective To study the relationship between gastric semi-solid emptying and serum nitric oxide (NO) in patients with liver cirrhosis.Methods Semi-solid meal mixed 10 little barium bar as markers were took by 33 patients with liver cirrhosis (Child-Pugh A 10 patients,Child-Pugh B 17,Child-Pugh C 6) and 14 volunteers and digital radiograghy was used for the estimation of gastric emptying time (GET).Fasting serum NO were also tested.Results GET of patients with liver cirrhosis and their serum NO were 6.38±1.1 hours and 66.46±11.96μmol/L respectively,volunteers were 4.94±1.87 hours and 50.23±9.7μmol/L as well.There were significant differences between patients and volunteers.GET and serum NO have no differences between patients of Child-Pugh A,B,C.Conclusion In contrast to the volunteers,in the patients with liver cirrhosis,GET of semi-solid meal is delayed in the patients with liver cirrhosis,NO plays an important role in the abnormality of gastric emptying in liver cirrhosis patients.Semi-solid meal GET has no relationship with Child-Pugh Class.Radiograpy is a kind of method suggested to be used. ......