【摘要】 目的 研究血糖控制不佳的糖尿病患者和非糖尿病患者患普通感冒(CC)时应用抗生素的不同疗效。方法 随机对照的试验方法，对照组仅服日夜百服宁，抗生素组加用抗生素，随访7天，并根据CC症状仅限于鼻咽部或同时伴咳嗽、发热分亚组分析。结果 非糖尿病组(A组)150例，随机分组为抗生素组71例，对照组79例，2组治愈率差异无显著性(P>0.05)。糖尿病组(B组)120例，与A组相比，其症状较少，局限于鼻咽部，易伴发热、咳嗽，易并发肺炎。抗生素组(69例)，治愈率高于对照组(51例，P<0.01)。亚组分析示伴有咳嗽的普通感冒患者抗生素治疗较有效。结论 非糖尿病患者患CC时服用抗生素并不改善预后。糖尿病患者血糖控制不佳时患CC症状较重，易迁延不愈及引起并发症，抗生素治疗可提高治愈率，尤其在伴有咳嗽症状时更有益。

    【关键词】 普通感冒；糖尿病；抗生素；疗效

    Effects of antibiotics on common cold in diabetic patients

    HUANG Yun-hong,WU Yi-jie,PENG Yong-de.

    Department of Endocrinology,Shanghai First People’s Hospital,Shanghai 200080,China

    【Abstract】 Objective To study the effects of antibiotics treatment on prognosis of common cold (CC) in non-diabetic and diabetic patients with poor glucose control.Methods Using randomized controlled trial,the patients were divided into control group or antibiotic group.Both groups took Bufferin Cold and the latter plus antibiotics during 7 days treatment.The results of treatment were evaluated by re-dividing into different subgroups,according to only with nasopharynx symptoms or accompanied with cough or fever.Results Non-diabetic CC (150 cases) were randomized into antibiotic group (71 cases) and control group (79 cases),no difference in cure rate was found between groups. Compared to non-diabetic ones,diabetic CC (120 cases) have symptoms which less restricted in nasopharynx and more accompanied by cough and also more complicated by pneumonia.The cure rate in diabetic CC was significantly higher in antibiotic group (69 cases) than in control group (51 cases) (P<0.01) ......