多药耐药性_____VX2细胞;

高温合并化疗对耐药性VX2细胞多药耐药基因的影响

http://www.100md.com 《第四军医大学学报》 2004年第3期

多药耐药性,,VX2细胞;,多药耐药性;,P糖蛋白;,热化疗,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Effect of thermochemotherapy on multidrugresistant VX2 cell MDR gene

    FAN AiLin, LIU GuoPeng, MA Jing, WANG ZhiMin, ZHENG ShanLuan, YANG MaiGui, HAO XiaoKe

    1Department of Clinical Laboratory, Xijing Hospital, 2Center of Teaching Experiment, School of Basic Medicine, 3Department of Chinese Traditional Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710033, China, 4Department of Interventional Radiology, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China

    【Abstract】 AIM： To observe the effect of thermochemotherapy on VX2 mdr1 cells MDR gene. METHODS: VX2 cells received hyperthermia (42.5℃ for 1 h), chemotherapy (ADM 32 μg/mL) and hyperthermia plus chemotherapy (42.5℃ for 1 h + ADM 32 μg/mL) respectively. The survival rate of cells and the expression of mdr1 mRNA and Pgp after thermochemotherapy were determined. RESULTS: The survival rate of the cells receiving hyperthermia plus chemotherapy was significantly lower than that of the cells receiving hyperthermia and chemotherapy respectively. After hyperthermia puls ADM, a lower (or lost) expression of mdr1 mRNA and lower expression of Pgp of VX2 mdr1 cells were found. CONCLUSION: Thermochemotherapy can decline tumor cell’s expression of mdr1 mRNA and Pgp, reverse tumor cell’s MDR, enhance the sensitivity of tumor cells to drugs. ......

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