Expressions and correlation of survivin and cyclooxygenaseª²2 in pancreatic andenocarcinoma tissues

    LIU Jiangª²Wei, LI Kaiª²Zong, DOU Keª²Feng, MA Fuª²Cheng, WANG Yingª²Mei

    1Department of Hepatobiliary Surgery, 2Department of Pathology, Xijing Hospital, Fourth Military Medical University£¬ Xi¡¯an 710033£¬ China

    ¡¾Abstract¡¿ AIM: To investigate correlation of the expression of survivin and cyclooxygenaseª²2 (COXª²2) and the clinicobiological behavior in human pancreatic adenocarcinoma tissues. METHODS: The expressions of survivin and COXª²2 in 51 cases of human pancreatic ductal adenocarcinoma were detected with immunohistochemistry of Envision. RESULTS: The expression rates of survivin and COXª²2 in pancreatic ductal adenocarcinoma were 80.4% and 74.5%, respectively, and no expression of survivin and COXª²2 in the 11 cases of adjacent normal tissues was found. The survivin expression was significantly correlated with the histological grade (P<0.01), but not with the clinical stages and lymph node metastasis status (P>0.05). The COXª²2 expression was significantly correlated with the clinical stages and lymph node metastasis status (P¡Ü0.05) but not with the histological grades (P>0.05). The expression of surviving and COXª²2 had no correlation with age, sex, tumor size and location but the expression of survivin was closely correlated with that of COXª²2 (P<0.05). CONCLUSION: The intimate relation of survivin and COXª²2 may play an important role in the tumorigenesis and tumor progression in pancreatic cancer, and they may provide some new targets for the therapy of pancreatic cancer. ......