WANG Hanª²Min, WANG Wen, LIU Yaª²Ling

    1Department of Nephrology, Xijing Hospital, 2Department of Health Statistics, School of Preventive Medicine, Fourth Military Medical University, Xi'an 710033, China

    ¡¾Abstract¡¿ AIM: To observe changes of serum sCD23 levels in uremic patients with maintaining hemodialysis (MHD) using different types of dialyzers. METHODS: The serum levels of sCD23 in uremic patients during hemodialysis were measured by double antibody with ELISA. Three kinds of dialyzers (cellulose acetat, hemophan and polysulfone) were used. The patients were divided into first use and reuse groups. RESULTS: At 15th minute after HD, the levels of sCD23 increased rapidly [CA (23¡À11) U/mL£¬ HE (18¡À5) U/mL£¬ PS (19¡À8) U/mL] in MHD patients firstly using dialyzers. Thereafter, the levels of sCD23 gradually decreased. There was no significant difference in sCD23 levels between initial [CA (13¡À7) U/mL£¬ HE (12¡À9) U/mL£¬ PS (12¡À6) U/mL] and the end of a single session [CA (15¡À9) U/mL£¬ HE (12¡À6) U/mL£¬ PS (14¡À7) U/mL] (P>0.05). The effect of cellulose acetat dialyzer on sCD23 was significantly different with that of hemophan and polysulfone dialyzers (P<0.05). The levels of sCD23 were not significantly different between the different kinds of dialyzer in reuse group. CONCLUSION: The regular changes of the levels of sCD23 may lead to decreased immune function in MHD patients, which are associated with the membrane's biocompatibility. The reuse of the dialyzer may ameliorate membrane biocompatibility. ......