妊娠并发症_____妊娠并发症,_心血管；

脯氨酰4羟化酶基因在妊高征胎盘中的表达及其临床意义

http://www.100md.com 《第四军医大学学报》 2004年第3期

妊娠并发症,,妊娠并发症,心血管；,高血压；,脯氨酰4羟化酶；,胎盘,0引言,1对象和方法,2结果,3讨论,【参考文献】

     Expression of prolyl4hydroxylase gene in placenta of patients with pregnancy induced hypertension and its clinical significance

    ZHU XiaoPing, YAO YuanQing

    Department of Obstetrics and Gynecology, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China

    【Abstract】 AIM: To investigate the expression of prolyl4hydroxylase (P4H) gene in the placenta of patients with pregnancy induced hypertension (PIH). METHODS: By using semiquantitative RTPCR, the mRNA levels of PIH and βactin of the patients with PIH and of the normal pregnant woman were measured and then compared. RESULTS: The ratio of P4H to βactin in control group was 0.38682±0.07931, and that in PIH group was 0.45671±0.05803, which suggested that mRNA level of P4H in PIH group was significantly higher than that in control group. CONCLUSION: Overexpression of P4H gene might play an important role in pathogenesis and pathophysiology of PIH.

    【Keywords】 pregnancy complications, cardiovascular; hypertension; prolyl4hydroxylase; placenta

    【摘要】目的: 通过检测脯氨酰4羟化酶(P4H)基因在妊娠高血压综合征(妊高征)患者胎盘中的表达,了解其在妊高征病理生理机制中的作用. 方法: 采用半定量RTPCR技术检测10例正常妊娠妇女(对照组)及10例中、重度妊高征患者(妊高征组)胎盘组织P4H和βactin mRNA水平. 结果: P4H与βactin积分吸光度比值在对照组和妊高征组胎盘组织中分别为:0.38682±0.07931; 0.45671±0.05803. 显示P4H mRNA在对照组和妊高征组胎盘组织中均有表达 ......

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