Treatment of rabbit hepatic neoplasm with radiofrequency ablation

    ZHAO Huaª²Dong, MA Qingª²Jiu, LAI Daª²Nian, LU Jianª²Guo, CHU Yanª²Kui, DU Xiª²Lin, HE Xianª²Li, BIAN Ling, BAO Guoª²Qiang

    Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi¡¯an 710038, China

    ¡¾Abstract¡¿ AIM: To analyze the therapeutic effect and significances of radiofrequency ablation (RFA) on the hepatic neoplasm. METHODS: The hepatic neoplasm animal model was established by injecting the VX2 tumor constitution mass into the liver of the rabbits. The animal models were randomly divided into the control group (before RF), and 0, 1, 3, 5,7 and 14 d groups after RF, and then the changes of hepatic function, hepatic neoplasm ultrasonography and pathology were observed respectively. RESULTS: Hepatic function changed apparently in 1 week and restored gradually to the normal level in 2 week (P<0.05). The size of neoplasm changed little in 1 week after RF and then reduced gradually. The neoplasm tissue formed necrosis, injury and inflammation regions after RF. Some of necrosis regions liquefied, and some of injury regions formed necrosis. Cell apoptosis occurred in the therapeutic region widely. CONCLUSION: The therapeutic effect of RF on the hepatic neoplasm is positive. Cell apoptosis is one of the key mechanism of RF treatment of the hepatic neoplasm. ......