Expression of hPTTG1 and cª²Myc in gallbladder carcinoma

    WANG Jiang, DOU Keª²Feng

    Department of Hepatobiliary Surgery, Xijing Hospital , Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To investigate the expression of hPTTG1 and cª²Myc in human carcinoma of gallbladder and their correlation with clinicobiological behavior and to probe the possible mechanism of their association. METHODS: The expressions of hPTTG1 and cª²Myc in 41 cases of human gallbladder carcinoma and 22 cases of chronic cholecystitis were detected with immunohistochemistry by SP. RESULTS: The positive rates of hPTTG1 and cª²Myc were 82.9% and 63.4% respectively, which were significantly higher in gallbladder carcinoma than in chronic cholecystitis (P = 0.002, 0.002). The expression of hPTTG1 was significantly associated with clinical stages and lymph node metastasis status (P=0.025, 0.007) but not with the histological grade (P=0.144). The expression of cª²Myc was significantly correlated with lymph node metastasis status(P=0.032), but not with histological grades and clinical stages (P=0.127, 0.198). There was a significant relation between the expression of hPTTG1 and cª²Myc (r= 0. 463, P = 0.002). Neither of the expressions had relation with age, sex, tumor type and cholelithiasis. CONCLUSION: hPTTG1 and cª²Myc may play a pivotal role in the tumorigenesis and tumor progression in gallbladder carcinoma. They can be used as important markers of invasiveness of gallbladder carcinoma and may provide new targets for therapy of gallbladder cancer. ......