【摘要】 目的 研究氨磷汀局部贴敷对放射性牙齿、牙髓及齿龈损伤的保护作用。方法 37只豚鼠分为A、B、C三组，A组5只为空白对照组，B、C组各16只分别为3个月和6个月观察组，以钴-60γ射线照射，射野包括上下齿、齿龈、双侧唾液腺，700cGy/次，连续4天，总剂量2800cGy。照射前1h用氨磷汀棉片保护B、C组豚鼠上齿及齿龈黏膜。下齿及齿龈仅照射不用药，A组不加任何干预。结果 B、C组下齿齿龈黏膜红肿，齿面粗糙，6个月后齿龈黏膜红肿好转，齿面粗糙仍旧，半年内共有6只下齿折断，受氨磷汀保护的上齿半年内共有1只牙齿折断，两组比较差异有显著性(P<0.05)。光镜下可见下齿齿龈黏膜纤维组织增生，厚度增加，而以3个月时明显，牙本质小管结构模糊，电镜下可见牙髓血管内皮细胞的胞核电子着色变浅，胞质中见肿胀的线粒体，其嵴间隙扩大，基质出现空化。受氨磷汀保护的上齿齿龈黏膜红肿明显比下齿龈黏膜减轻，牙本质小管结构轻度模糊，其放射损伤程度与下齿相比差异有非常显著性(P<0.01)，电镜下可见牙髓血管内皮细胞结构基本正常。结论 氨磷汀放疗前1h牙齿及齿龈黏膜局部贴敷用药，对放射性牙齿及齿龈损伤有一定保护作用，远期效果有待进一步观察。

    【关键词】 氨磷汀；放射治疗；牙齿；齿龈

    The micrograph of topical application of amifostine for prevention of radiation-induced teeth damage

    WANG Sheng-zi，WANG Shu-yi，LI Ji，et al.

    The Affiliated Hospital of Ophthalmic Otorhinopharynology，Fudan University，Shanghai 200031，China

    【Abstract】 Objective The cytoprotective agent amifostine has been shown to reduce the radiation-induced xerostomia and teeth damage in head and neck cancer patients. The purpose of this study was to evaluate whether or not topical application of amifostine also reduces the incidence of radiation-induced teeth and gum damage.Methods The status of teeth and gum in 3 month(group B) and 6 month(group C) after radiation was compared in 37 guinea pigs ......