骨形态发生蛋白质_____气管；_移植；

BMP诱导自体气管移植段软骨再生的量效关系

http://www.100md.com 《第四军医大学学报》 2004年第5期

骨形态发生蛋白质,,气管；,移植；,骨形态发生蛋白质,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Dosedependent effects of cartilage regeneration induced by BMP in tracheal autograft

    LI XiaoFei, ZHANG Tao, CHENG QingShu, LIU Kun, LU Qiang, WANG Jian

    Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China

    【Abstract】 AIM: To investigate the dosedependent effects of cartilage regeneration induced by rhBMP2 in tracheal autograft. METHODS: Different concentration of rhBMP2 was administrated to the canine trachea autograft, and then the autografts were heterotopically transplanted into the omentum. The autografts were harvested after 4 weeks and the morphologic changes of the autografts were observed by light microscope. The area of regeneration cartilage was measured. RESULTS: The area of regeneration cartilage increased along with the concentration of rhBMP2 (P<0.05). But it increased slowly when the concentration of rhBMP2 was above 5 mg (P>0.05). CONCLUSION: These results indicate that 5 mg rhBMP2 can be an appropriate dose in canine tracheal autografts.

    【Keywords】 trachea；transplantation；bone morphogenetic protein ......

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