Alterations of praxiology and biochemistry in multiª²infarction dementia rats and protective effects of COª²GBE

    ZHANG Aiª²Lin, XU Qiuª²Ping, SUN Jianª²Ning, WU Yan, GUO Jing, YE Zhengª²Liang, ZHANG Shunª²Nan, SUN Xin

    1Department of Pharmacy, College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China, Tianjin TASLY Pharmaceutical CO. LTD., Tianjin 300402, China

    ¡¾Abstract¡¿ AIM: To study the protective effects of COª²GBE on multiª²infarction dementia (MID) rat model. METHODS: The multiª²infartion dementia model was induced by injecting thromboembolus of the same kind of rats into the internal carotid artery.The protective effects of COª²GBE was observed by detecting the changes in the learning and memorizing abilities and biochemical metabolism in brain. RESULTS: All three doses of COª²GBE (10 mg/kg, 20 mg/kg, 40 mg/kg) improved the learning and memorizing abilities by different degrees£¬which was confirmed in Morris water maze test. The escaping latency and the time for passing through target for the first time were shortened significantly. The biochemical assay showed that the acetylcholinesterase activity decreased and the lactic acid content increased in hippocampus and cortex in model rats. COª²GBE reversed these abnormality by different degrees. CONCLUSION: Ameliorating cholinergic nervous system function and restraining lactic acid content may be the active mechanisms of COª²GBE in improving the learning and memorizing abilities, protecting encephalon and preventing vascular dementia in MID rats. ......