小神经胶质细胞__(期刊论文)

脂多糖诱导大鼠延髓神经元FOS和小胶质细胞OX42表达水平的变化

http://www.100md.com 《第四军医大学学报》 2004年第8期

小神经胶质细胞,,小神经胶质细胞；脂多糖类；延髓；Fos；OX42；神经免疫调节,0引言,1材料和方法,2结果,3讨论,【参考文

     Expression changes of Fos protein in neurons and OX42 in microglias of rat MVZ after intraperitoneal lipopolysaccharide injection

    GAO Bei, LAN Li, RAO ZhiRen

    PLA Institute of Neurosciences, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To investigate the expressions of Fos positive neurons and OX42 positive microglias in rat medullary visceral zone (MVZ) activated by a single intraperineal (IP) injection of lipopolysaccharide (LPS). METHODS: AntiFos and antiOX42 immunohistochemical ABC technique was used to investigate the medullary sections from different rates killed at 0.5, 1, 3, 6, 12, 24 and 72 h respectively after LPS injection. RESULTS: ① Fos positive neurons (FosLI) appeared at 1 h and peaked at 3 h after injection. These neurons were mainly located in MVZ. ② OX42 positive microglias appeared at 3 h and peaked at 12 h after injection. They were located in the MVZ, paratrigeminal nucleus and external cuneate nucleus. CONLUSION: The neurons and microglias in MVZ can sensitively respond to LPS injection. The peak time of the activated neurons is earlier than that of the activated microglias. ......

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