Study of the long-term epidemiological efficacy of inactivated vaccine against EHF in Guizhou

    Chengli Hea,Guoqin Liub,Yixiong Zhangb,Wanbang Sunb,Xuegui Huangb

    Abstract OBJECTIVE To observe the long-term epidemiological efficacy of inactivated vaccine against EHF.METHODS Indirect immunofluorescent antibody assay (IFA) was used to test the specific IgG antibody.RESULTS The effect of the vaccine after primary immunization, enhancement inoculation and immunization again this time were 0.04%, 0.09% and 3.42% respectively. Serumfluorescent antibody positive rate were 40.54%, 75.00% and 85.23%. Their protection rates in population were 83.11% and 95.10% for primary immunization and 1 year after primary immunization, and the protection rate against EHF per year was 77.84% from 1992 to 2001. The GMT was increased from 40.29 to 71.13 after inoculated again.CONCLUSION The inactivated EHF vaccine was safe. It also showed epidemiological efficacy. According to the observation, we can concluded that it is necessary for people who underwent the whole course inoculation to inoculated again timely. ......