Autologous hematopoietic stem cell mixed allogeneic HLA haploidentical bone marrow transplantation in the treatment of hematological malignancies

    OU Yingª²Xian, PAN Yaoª²Zhu, BAI Hai, WANG Cunª²Bang, DA Wanª²Ming, WEI Yaª²Ming, WANG Xiaoª²Jing, L¨¹ Guiª²Ling

    1Department of Hematology, Lanzhou General Hospital, Lanzhou Military Command, Lanzhou 750050, China, 2Department of Hematology, PLA General Hospital, Beijing 100853, China

    ¡¾Abstract¡¿ AIM: To investigate clinical outcome and the treatmentª²related complications in patients with hematological malignancies undergoing autologous hematopoietic stem cell mixed allogeneic HLA haploidentical bone marrow transplantation. METHODS: We analyzed retrospectively the clinical data of 33 hematological malignancy patients from January 1995 to January 2003. RESULTS: Seventeen (51%) of all 33 developed mild or moderate oral mucitis,1 severe hemorrhagic cystitis,1 hepatic VOD,1 leukoencephalopathy, 1 cerebral edema after TBI,1 interstitial pneumonia due to tuberculous preurisy during transplantation.10 cases evaluable were analysed: 3 cases developed mixed chimera,and 2 cGVHD. With a median follow up of 42 months (range 6 to 96), 19 patients(57.6%) are still in diseaseª²free survival, 4(12.1%) patients died from transplantation related toxicity, 8(24.2%) relapsed post transplantation,2(6.1%) developed MDS post transplantation. CONCLUSION: These results indicate that autologous hematopoietic stem cell mixed allogeneic HLA haploidentical bone marrow transplantation can induce GVL effect and reduce relapse post transplantation,without an increased incidence of transplantation related mortality or toxicity. ......