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    Clinical application of human tissueª²engineered active skin with full thickness on deep burn wounds

    LIU Yaª²Ling, JIN Yan, NIE Xin, HU Daª²Hai

    1Department of Burn Surgery, Center of Plastic Surgery, Xijing Hospital, 2Department of Oral Histology and Pathology, Stomatological College, Fourth Military Medical University, Xi¡¯an 710033, China

    ¡¾Abstract¡¿ AIM: To observe the clinical effect of human tissueª²engineered active skin (ActivSkin) with full thickness on deep burn wounds. METHODS: Thirtyª²one cases of deep burn wounds were repaired with human tissueª²engineered active skin. The time to complete closure and the ratios of complete healing for ActivSkinª²treated wounds were observed. The effect of sexual identity of ActivSkin recipients (patients) and donors on complete healing was observed. All the patients were followed up. RESULTS: Compared to control group, the time to complete closure in ActivSkin therapy group was shortened by 6 d for 25 deep second degree burn wounds (P<0.05), and by 20 d for 6 fullª²thickness burn wounds (P<0.05). The ratios of complete healing in ActivSkin therapy group and control group were both 100%. The sexual identity of recipients (patients) and skin donors had no influence on the time of complete closure of wounds (P>0.05). The followª²up results showed that ActivSkin might be admited by recipients and degraded after application. We did not detect the immunological rejection and inflammatory reaction in recipient area after ActivSkinª²treatment. CONCLUSION: ActivSkin is a new bioactive skin substitute for the repairing of deep burn wounds. ......