晶体上皮细胞_____反义寡核苷酸；半乳糖；晶体上皮细胞

反义bcl2寡核苷酸对半乳糖诱导的晶体上皮细胞的抑制作用

http://www.100md.com 《第四军医大学学报》 2004年第5期

晶体上皮细胞,,反义寡核苷酸；半乳糖；晶体上皮细胞,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Inhibitory effects of antisense oligodeoxynucleotide bcl2 on lens epithelial cells induced by galactose

    LI ChangFu, FAN Fang, GE ZhengLong, LI HaiXiang, ZENG XiaoPing

    1Department of Biochemisty, 2Department of Ophthalmology, Affiliated Hospital, Zunyi Medical College, Zunyi 563003, China

    【Abstract】 AIM: To investigate the effects of antisense oligodeoxynucleotide bcl2 (bcl2 ASODN) on the growth of rabbit lens epithelial cells (LEC) induced by galactose. METHODS: Oligonucleotides, which complemented with translation initiation region of bcl2 gene, were synthesized and modified with phosphorothioate. Lens epithelial cells were treated with galactose and bcl2 ASODN. The effects of bcl2 ASODN on the growth of LECs, which were cultured in high galactose, were analyzed by cell counts and methyl thiazolyl tetrazoliuym (MTT) assay. RESULTS: 2.5-10.0 μmol/L bcl2 ASODN inhibited the growth of LEC induced by galactose in a dosedependent manner. CONCLUSION: bcl2 ASODN can inhibit the growth of LEC induced by galactose. ......

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