Study on immunogenicity of hepatitis B vaccine by accelerated schedule or by twoª²dose schedule

    YUAN Yueª²Bin, ZHU Jieª²Gen, DUAN Xinª²Ke, WANG Zhongª²Qian

    1Department of Infectious Diseases, 152 Hospital of Chinese PLA, Pingdingshan 467000, China, 2Medical Regiment, Unit 71872 of Chinese PLA, Xinyang 464000, China

    ¡¾Abstract¡¿ AIM: To study the immunogenicity of hepatitis B vaccine by accelerated schedule or by twoª²dose schedule. METHODS: One hundred and fifty subjects were randomly divided into A, B and C groups and were vaccinated by standard schedule, accelerated schedule or twoª²dose schedule, respectively. The antibody response was determined at 1st month, 3rd month, 7th month and 12th month. RESULTS: One month after the first vaccine injection, the seroconversion rate of group B (64.0%) was higher than that of group A (26.0%, P<0.01) or that of group C (28.0%, P<0.01), and the mean geometric titer (GMT) of group B was higher than that of group A or group C (P<0.01). So was the case at 3rd month. At 7th or 12th month, the seroconversion rates had no difference between the three groups, but at 7 month, the GMT of group A was higher than group B or group C. CONCLUSION: Accelerated schedule provides protective antibody titers with a shorter time compared to the standard schedule, and the twoª²dose schedule is costª²effective in achieving protective immuogenicity. ......